Effect of the ACTN-3 gene polymorphism on functional fitness and executive function of elderly

Henrique, Jessica Salles and Braga, Pedro Luiz Garcia and Almeida, Sandro Soares de and Nunes, Nathalia Santanna Petraconi and Benfato, Izabelle Dias and Arida, Ricardo Mario and de Oliveira, Camila Aparecida Machado and Gomes da Silva, Sérgio (2022) Effect of the ACTN-3 gene polymorphism on functional fitness and executive function of elderly. Frontiers in Aging Neuroscience, 14. ISSN 1663-4365

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Abstract

During aging, physical integrity and cognitive abilities, especially executive function, become compromised, directly influencing the quality of life of the elderly. One good strategy to ensure healthy aging is the practice of physical exercise. Activities to improve aerobic capacity and muscle strength are extremely important in old age. However, some genetic factors can interfere both positively and negatively with these gains. In this context, the polymorphism rs1815739 (R577X) of the α-actinin 3 gene (ACTN-3) is commonly studied and related to muscle phenotype. Thus, the present study aimed to investigate the effect of the ACTN-3 gene polymorphism on the functional fitness (measured by the Senior Fit test) and cognitive capacity (evaluated by the Stroop test) of the elderly (n = 347), both men and women. We did not find the effect of genotype on functional fitness, but we did observed a positive effect of the ACTN-3 gene polymorphism on executive function. The presence of the X allele of the ACTN3 gene in the elderly was related to a better performance in the Stroop test (shorter answer time). Our results showed that ACTN-3 gene polymorphism affects the executive function of the elderly but not their functional fitness.

Item Type: Article
Subjects: STM Article > Medical Science
Depositing User: Unnamed user with email support@stmarticle.org
Date Deposited: 01 Mar 2024 04:27
Last Modified: 01 Mar 2024 04:27
URI: http://publish.journalgazett.co.in/id/eprint/1870

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