Effects of one period of moderate exercise (MI) on serum levels of leptin, Blood Lactate, lipid profiles and lung function in obese sedentary men

Background: Adipose tissue has an important role in inducing lung dysfunction through production and secretion of adipokins such as leptin. The purpose of this study was to investigate the effect of 12 weeks of moderate intensity exercise training on Lung function, serum leptin levels and lipid profile in inactive obese men.

Methods: This research was conducted with a semi- experimental methodology with pre-test and post-test. Twenty-two inactive obese men (18 to 30 years old) voluntarily participated in this study and randomly divided into two exercise (n = 11) and control (n = 11) groups. Subjects performed moderate intensity aerobic exercise training for 12 weeks. Blood samples were collected after overnight fasting, before and after the 12-week of exercise training program. Serum leptin levels, Lipid profile and pulmonary function were measured before and after of 12 week moderate intensity exercise training. All statistical tests (paired sample T-test, Independent T-test, Pearson correlation coefficient) were performed and considered significant at a p≤0.05.

Results: The results of this study showed that after 12 weeks of moderate intensity exercise levels of triglyceride (P=0.001), cholesterol (P=0.001), leptin (P=0.001), LDL (P=0.001), and VLDL (P=0.01) decreased and HDL (P=0.001) increased after 12 weeks of aerobic exercise compared to baseline in exercise group. Also FVC (P=0.022) and MVV (P=0.02) significantly increased.

Conclusion: Twelve week of moderate intensity exercise training caused favorable changes in lipid profile, obesity-related metabolic biomarkers and Pulmonary function in inactive obese men.